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Year : 2017  |  Volume : 6  |  Issue : 1  |  Page : 115-119

Correlation of Vitamin D with metabolic parameters in polycystic ovarian syndrome

1 Department of Nephrology, Command Hospital, Lucknow, Uttar Pradesh, India
2 Department of Medicine, Command Hospital, Udhampur, Jammu and Kashmir, India
3 Department of Pathology, Base Hospital, Delhi Cantonment, New Delhi, India
4 Department of Medicine, Military Hospital, Faizabad, Uttar Pradesh, India
5 Department of Endocrinology, Army Hospital (R&R), New Delhi, India

Correspondence Address:
K. V. S. Hari Kumar
Department of Endocrinology, Army Hospital (R&R), Delhi Cantt, New Delhi - 110 010
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2249-4863.214985

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Background: Polycystic ovarian syndrome (PCOS) and hypovitaminosis D are the two most common endocrine disorders in young women leading to many adverse metabolic consequences. We evaluated the correlation of 25-hydroxy Vitamin D (25OHD) with metabolic parameters and insulin resistance in PCOS. Materials and Methods: We included 100 PCOS patients (age 18–40 years, duration >6 months) serially, in this cross-sectional study. We excluded patients with past use of insulin sensitizers and hormone therapy. All patients underwent a physical examination, body fat estimation, and a single fasting blood sample was analyzed for the biochemical parameters. The patients were divided into 2 groups as per the 25OHD level: Group 1 (Deficient, <30 ng/mL) and Group 2 (normal). The data were analyzed using appropriate statistical methods, and aP< 0.05 was considered statistically significant. Results: The study population had a mean age of 28.6 ± 6.3 years, body mass index (BMI) 30.4 ± 6.1 kg/m2 and body fat of 39.1 ± 13%. A total of 90 women had 25OHD deficiency, and hypovitaminosis D was observed more in younger, obese patients. Patients with hypovitaminosis D had a higher BMI (P = 0.0124), low- high-density lipoprotein (P = 0.0094), calcium (P ≤ 0.0001), and elevated testosterone (P = 0.0412) in comparison with normal 25OHD patients. None of the metabolic parameters showed significant correlation with 25OHD (P > 0.05). Conclusion: Hypovitaminosis D is very common in PCOS patients and exacerbates the metabolic abnormalities. It is essential to screen all the PCOS patients for 25OHD deficiency, and further large-scale studies are required to confirm our findings.

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