World Rural Health Conference
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 6
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 


 
 Table of Contents 
ORIGINAL ARTICLE
Year : 2018  |  Volume : 7  |  Issue : 3  |  Page : 577-580  

Prevalence of Helicobacter pylori infection in upper gastrointestinal tract disorders (dyspepsia) patients visiting outpatient department of a hospital of North India


1 Department of General Surgery, AIIMS, Bhopal, Madhya Pradesh, India
2 Department of Community Medicine, GMC, Bhopal, Madhya Pradesh, India

Date of Web Publication17-Jul-2018

Correspondence Address:
Dr. Puneet Kumar Agarwal
Department of Surgery, AIIMS, Bhopal - 462 026, Madhya Pradesh
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfmpc.jfmpc_213_17

Rights and Permissions
  Abstract 


Background: Helicobacter pylori infection is a major health ailment in developing countries. The infection is related with high morbidity and mortality ranging from chronic gastritis to gastric malignancies. The prevalence of H. pylori infection greatly varies from country to country and region to region. The aim is to study the prevalence of H. pylori infection in upper gastrointestinal (GI) tract disorders (dyspepsia) patients. Methods: The study was carried out in an outpatient department, India. Patients presenting with dyspeptic symptoms were subjected to serological investigation and upper GI endoscopy, histopathological examination, and rapid urease test of specimen. Diagnosis of H. pylori infection was made if one or both diagnostic test results were positive. Results: H. pylori infection was diagnosed in 85% of patients. There was no significant difference in sex- and age-related distribution (<50 years' age group and >50 years' age group) of H. pylori infection. However, association of H. pylori infection was positive in 83.3% (45) of patients with endoscopic abnormalities (54). Conclusion: The prevalence of H. pylori infection is high in the study population. Early detection and prompt treatment are essential for prevention of serious complications.

Keywords: Gastrointestinal complications, Helicobacter pylori infection, histopathological examination, rapid urease test


How to cite this article:
Agarwal PK, Badkur M, Agarwal R, Patel S. Prevalence of Helicobacter pylori infection in upper gastrointestinal tract disorders (dyspepsia) patients visiting outpatient department of a hospital of North India. J Family Med Prim Care 2018;7:577-80

How to cite this URL:
Agarwal PK, Badkur M, Agarwal R, Patel S. Prevalence of Helicobacter pylori infection in upper gastrointestinal tract disorders (dyspepsia) patients visiting outpatient department of a hospital of North India. J Family Med Prim Care [serial online] 2018 [cited 2018 Nov 15];7:577-80. Available from: http://www.jfmpc.com/text.asp?2018/7/3/577/236846




  Introduction Top


Helicobacter pylori infection is known to be among the most common human infections worldwide; approximately 50% of the world's population is infected with H. pylori[1] while most of the infected individuals are asymptomatic; it acts as a cofactor to produce gastrointestinal (GI) disorders (dyspepsia) in a small but significant minority.[2]H. pylori gastritis is the principal cause of chronic active gastritis and has major complications such as gastric adenocarcinoma and mucosa-associated lymphoid tissue lymphoma.[3]

A wide range of laboratory investigations are available for diagnosis of H. pylori. The tests belong to noninvasive group and invasive group. Noninvasive tests include urea breath test, serological immunoglobulin G and immunoglobulin M detection, saliva and urinary antibody test, and stool antigen test.[4] The invasive tests are endoscopy-based tests, which include histopathological examination, rapid urease test (RUT), and polymerase chain reaction.

H. pylori infection is among the leading gastroenterological public health problems in developing countries.[5] Approximately 80% of the population may be infected by the age of 20. In India, the prevalence of this infection is 22%, 56%, and 87% in the 0–4 years', 5–9 years', and 10–19 years' age group, respectively.[6]

However, data concerning the prevalence of H. pylori infection in Northern India are scanty; the present study has been undertaken to determine the prevalence and relationship between H. pylori infection in patients with different upper GI disorders.

Objectives

  1. To determine the prevalence of H. pylori infection in upper GI tract disorder patients visiting outpatient department of a hospital of Northern India
  2. Relationship of H. pylori infection with different upper GI disorders.



  Materials and Methods Top


This is a cross-sectional prospective study involving the observation of data of routinely advised investigations to patients complaining of upper GI symptoms (dyspepsia) visiting surgical outpatient department (OPD) after taking informed consent from each patient.

Patients were selected on the basis of chief complaints of dyspepsia (according to the Rome I criteria), and the age of patients ranged from 15 to 86 years. Patients were divided into two groups. Group “A” patients (younger than 55 years of age with dyspepsia who are without alarm features) underwent serologic testing for H. pylori. Group “B” patients (older than 55 years of age and/or those with alarm features, e.g., weight loss, progressive dysphasia, recurrent vomiting, evidence of GI bleeding, or family history of cancer) were advised for upper GI endoscopic (UGIE) evaluation, and biopsy was subjected to RUT test for H. pylori.

In Group A, 7 patients already had gone through the UGIE, before visit of OPD. Rest 46 patients were only investigated for serology. In Group B, all 47 patients went for UGIE with RUT.

The presence of H. pylori was determined by RUT and serology. Any test, if positive, was considered positive for H. pylori infection. The collected information was recorded on the pro forma (study instrument). Analysis was done by Epi Info software. Appropriate tests of significance such as Chi-square test and t-test were also applied.


  Results Top


During the study period, 100 patients were included in the study as per inclusion criteria. In study population, the age range (median) was 15–86 (50.3) years. Fifty-three patients (the age range [median] was 15–54 (35.8) years) were included as Group A and 48 patients (the age range [median] was 55–86 (66.78) years) were included as Group B.

In our study, we found total 41 (76%) patients out of 54, positive for H. pylori by RUT. By serology, we found 81% of patients positive. Collectively, total 85% of patients were found to be positive for H. pylori and 15 patients were negative.

The female (37)-to-male (63) ratio was 1–1.7 [Table 1]. The average age of male patients is 45.7 years, and the average age of female patients is 58.2 years [Table 2].
Table 1: Helicobacter pylori sex distribution

Click here to view
Table 2: Age distribution of Helicobacter pylori

Click here to view


In our study population, 62 patients belong to rural area and 38 were from urban area. Sixty-nine patients were strictly vegetarians whereas 31 were on mixed diet. Thirty-three patients accepted to have some kind of addiction in which 4 are females and rest are males, mostly aged between 30 and 50 years. We did not found any significant difference related to addiction in regard of the prevalence of H. pylori infection. Education status of the population varies from illiterate to master's degree. Total 11 patients were illiterate and a maximum number of patients were having a bachelor degree.

In this study, abdomen (epigastric) pain was reported by 81 patients, gastric fullness by 68, nausea by 71, vomiting by 25, fat intolerance by 13, bloating by 76, blenching by 67, melena by 4, and early satiety by 47 patients. Abdominal pain shows marginally significant raise in the prevalence of H. pylori; apart from this, there is no significant difference among other symptoms [Table 3].
Table 3: Correlation of symptoms with Helicobacter pylori infection

Click here to view


Total 54 patients' endoscopy report was evaluated, and out of them, chronic gastritis was noted in 11 (20.37%) patients, duodenal ulcer in 29 (53.7%) patients, gastric ulcer in 7 (12.9%) patients, and nonulcer dyspepsia in 7 (12.9%) patients [Table 4].
Table 4: Correlation of endoscopic abnormalities with Helicobacter pylori infection

Click here to view



  Discussion Top


Numerous epidemiological studies have shown substantial differences in the prevalence of H. pylori infection in the population studied. The infection rate is by and large higher and begins at an earlier age in developing as compared to developed countries, demonstrating an important role of socioeconomic status in its transmission.[2]

In developing country like India where resources are limited, especially the access to endoscopy services, it is important for clinicians to know common causes of dyspepsia and frequency of H. pylori infection. In our study, endoscopy and RUT were only advised to the selective patients, and data were analyzed. Serology being a noninvasive investigation and also does not require special technical expertise and was done in all the cases.

In the present study, we did not get a significant difference in H. pylori prevalence according to gender. In our study, male-to-female ratio is in concordance with the study done by Adlekha et al.,[7] Tarkhashvili et al.,[8] Isabelle et al.[9] and Shokrzadeh et al.,[10] but these result are in contrast with a study done by Kaore et al.,[11] which showed higher prevalence in male gender.

Age distribution of H. pylori infection did not show any trend toward increase or decrease in infection with the advancing age. There was no statistically significant difference in the prevalence of H. pylori in the age group of <50 years and >50 years. This is similar to the observations laid by Adlekha et al.[7] and Tarkhashvili et al.[8] and also a study done by Isabelle et al.,[9] in 2016, but in some studies like Shokrzadeh et al.[10] and Kaore et al.,[11] they have reported increased H. pylori infection in age groups of 20–40 years than the older age group.

In our study, 81% of patients complained abdominal pain which is somewhat similar to the study done by Segni M. Ayana et al.,[12] where epigastric pain was reported by 86.1% of patients with dyspepsia but in both the studies apart from this other clinical complaints greatly varies.

In our study, 87% of patients had organic causes which were diagnosed with endoscopy. This is consistent with the findings of the studies done in Ethiopia (Asrat et al.,[13] 2004) and Nigeria (Mustafa et al.,[14] 2007) where organic causes of dyspepsia were documented in 96.4% and 82.1% of patients, respectively. However, our finding differs from the findings of the studies done in Kate et al.,[2] and Adlekha et al.,[7] where organic causes of dyspepsia were documented in 73% and 67.1% of dyspeptic patients, respectively. A meta-analysis of 22 studies from the developed countries which is done by Tytgat et al.[15] showed abnormal endoscopic findings in only 51% of dyspeptic patients; similarly, in a study done by Eusebi et al.,[16] in 2014, the prevalence of infection ranged from 58% to 62% in patients with dyspeptic symptoms. This difference may be attributed to how patients were selected and the inclusion and exclusion criteria used in different studies, differences in socioeconomic status, and health-care seeking behavior.

In our study, duodenal ulcer and chronic gastritis were found to be the most common endoscopic abnormalities. Moreover, our study also demonstrated the association between H. pylori infection and duodenal ulcer, and chronic gastritis is statistically significant as also reported by Kate et al.[2] There is ample evidence regarding the beneficial role of H. pylori eradication therapy in patients with peptic ulcer disease and gastritis (Hopkins et al.[17] and Yi-Chia et al.[18]). Thus, clinicians should test and treat for the infection if resources are available. In resource-poor settings where confirmatory test is not available or may not be cost-effective, empirical therapy is recommended (World Gastroenterology Guidelines, 2010).

The present study certainly establishes the burden of H. pylori in the society. There is a need of another broader study in this region, assessing the association of different demographic and lifestyle factors, presenting complaints, role of different investigating modalities and preexisting conditions such as diabetes mellitus with prevalence of H. pylori infection, and follow-up of the patients after treatment and lifestyle modifications.


  Conclusion Top


The present study concludes that duodenal ulcer, gastric ulcer, nonulcer dyspepsia, and chronic gastritis are the most common etiologies of dyspepsia. H. pylori infection is still present in significant proportion of dyspeptic patients.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
  References Top

1.
Brown LM. Helicobacter pylori: Epidemiology and routes of transmission. Epidemiol Rev 2000;22:283-97.  Back to cited text no. 1
    
2.
Ratnakar C. Prevalence of helicobacter pylori infection in disorders of the upper gastrointestinal tract in South India. Natl Med J India 1998;11:5-8.  Back to cited text no. 2
    
3.
Ozbek A, Ozbek E, Dursun H, Kalkan Y, Demirci T. Can helicobacter pylori invade human gastric mucosa?: An in vivo study using electron microscopy, immunohistochemical methods, and real-time polymerase chain reaction. J Clin Gastroenterol 2010;44:416-22.  Back to cited text no. 3
    
4.
Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, et al. Current concepts in the management of helicobacter pylori infection: The Maastricht III consensus report. Gut 2007;56:772-81.  Back to cited text no. 4
    
5.
Mandeville KL, Krabshuis J, Ladep NG, Mulder CJ, Quigley EM, Khan SA, et al. Gastroenterology in developing countries: Issues and advances. World J Gastroenterol 2009;15:2839-54.  Back to cited text no. 5
    
6.
Das JC, Paul N. Epidemiology and pathophysiology of helicobacter pylori infection in children. Indian J Pediatr 2007;74:287-90.  Back to cited text no. 6
    
7.
Adlekha S, Chadha T, Krishnan P, Sumangala B. Prevalence of helicobacter pylori infection among patients undergoing upper gastrointestinal endoscopy in a medical college hospital in Kerala, India. Ann Med Health Sci Res 2013;3:559-63.  Back to cited text no. 7
[PUBMED]  [Full text]  
8.
Tarkhashvi l i N, Beriashvili R, Chakvetadze N, Moistsrapishvili M, Chokheli M, Sikharulidze M, et al. Helicobacter pylori infection in patients undergoing upper endoscopy, republic of Georgia. Emerg Infect Dis 2009;15:504-5.  Back to cited text no. 8
    
9.
Isabelle N, Ben V, Robert I, Michael R. Helicobacter pylori status among patients undergoing gastroscopy in rural Northern Alberta. Canadian Family Physician 2016;62:e547-54.  Back to cited text no. 9
    
10.
Shokrzadeh L, Baghaei K, Yamaoka Y, Shiota S, Mirsattari D, Porhoseingholi A, et al. Prevalence of helicobacter pylori infection in dyspeptic patients in Iran. Gastroenterol Insights 2012;4:247.  Back to cited text no. 10
    
11.
Kaore NM, Nagdeo NV, Thombare VR. Comparative evaluation of the diagnostic tests for helicobacter pylori and dietary influence for its acquisition in dyspeptic patients: A rural hospital based study in central India. J Clin Dianostic Res 2012;6:636-41.  Back to cited text no. 11
    
12.
Ayana S, Swai B, Maro V, Kibiki G. Upper gastrointestinal endoscopic findings and prevalence of Helicobacter pylori infection among adult patients with dyspepsia in northern Tanzania. Tanzan J Health Res 2014;16:16-22.  Back to cited text no. 12
    
13.
Asrat D, Nilsson I, Mengistu Y, Ashenafi S, Ayenew K, Abu al-soud W, et al. Prevalence of H. pylori infection among adult dyspeptic patients in Ethiopia. Ann Trop Med Parasitol 2004;98:181-9.  Back to cited text no. 13
    
14.
Mustapha SK, Bolori MT, Ajayi NA, Nggada HA, Pindiga UH, Gashau W, et al. Endoscopic findings and the frequency of Helicobacter pylori among dyspeptic patients in northeastern Nigeria. Internet J Gastroenterol 2007;6.  Back to cited text no. 14
    
15.
Tytgat GN. Role of endoscopy and biopsy in the work up of Dyspepsia. Gut 2002;50 (Suppl IV):iv13–iv16.  Back to cited text no. 15
    
16.
Eusebi LH, Zagari RM, Bazzoli F. Epidemiology of helicobacter pylori infection. Helicobacter 2014;19 Suppl 1:1-5.  Back to cited text no. 16
    
17.
Hopkins RJ, Girardi LS, Turney EA. Relationships between H. pylori eradication and reduced duodenal and gastric ulcer recurrence: A review. Gastroenterology 1996;110:1244-52.  Back to cited text no. 17
    
18.
Lee Y, Chen T, Chiu H, Shun C, Chiang H, Liu T, Wu M, Lin J. The benefit of mass eradication of Helicobacter pylori infection: A community-based study of gastric cancer prevention. Gut 2012;62:676-82.  Back to cited text no. 18
    



 
 
    Tables

  [Table 1], [Table 2], [Table 3], [Table 4]



 

Top
   
 
  Search
 
Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
Access Statistics
Email Alert *
Add to My List *
* Registration required (free)

 
  In this article
   Abstract
  Introduction
   Materials and Me...
  Results
  Discussion
  Conclusion
   References
   Article Tables

 Article Access Statistics
    Viewed338    
    Printed2    
    Emailed0    
    PDF Downloaded93    
    Comments [Add]    

Recommend this journal