|LETTER TO EDITOR
|Year : 2018 | Volume
| Issue : 6 | Page : 1589-1590
Poncet's disease: Uncommon musculoskeletal manifestation of tuberculosis
Harpreet Singh, Ashok K Pannu, Vikas Suri, Ashish Bhalla, Savita Kumari
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh, India
|Date of Web Publication||30-Nov-2018|
Dr. Ashok K Pannu
Department of Internal Medicine, Post Graduate Institute of Medical Education and Research (PGIMER), 4th floor, F block, Chandigarh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Singh H, Pannu AK, Suri V, Bhalla A, Kumari S. Poncet's disease: Uncommon musculoskeletal manifestation of tuberculosis. J Family Med Prim Care 2018;7:1589-90
|How to cite this URL:|
Singh H, Pannu AK, Suri V, Bhalla A, Kumari S. Poncet's disease: Uncommon musculoskeletal manifestation of tuberculosis. J Family Med Prim Care [serial online] 2018 [cited 2019 Jun 15];7:1589-90. Available from: http://www.jfmpc.com/text.asp?2018/7/6/1589/246499
We found the article by Gupta and Bhatnagar, 'Musculoskeletal manifestations of tuberculosis: An observation study,' interesting. However, Poncet's disease, a form of reactive arthritis seen in patients of tuberculosis, was not mentioned in detail. We would like to discuss this entity as a case we encountered in our institute recently. A 27-year-old female presented with complaints of intermittent fever associated with chills of 3 weeks duration, which was associated with pain and swelling of bilateral ankles, wrists and knee joints. Patient also had bilateral erythema nodosum on shins. On clinical examination, liver, spleen and peripheral lymph nodes were non-palpable. Laboratory investigations showed erythrocyte sedimentation rate (ESR) 66 (reference range; 2–20), C-reactive protein (CRP) 39 IU/ml (reference range; 0–5 IU/ml) and rheumatoid factor (RF) 2.08 (reference range 0–14 IU/ml). Tuberculin sensitivity test was 20 mm after 72 h. Chest radiograph showed mediastinal widening suggestive of lymphadenopathy. A computed tomography of chest showed multiple necrotic mediastinal lymph nodes [Figure 1]. Radiography of bilateral elbow joints was normal. She was started on category I antitubercular treatment (isoniazid 5 mg/kg, rifampicin 10 mg/kg, pyrazinamide 25 mg/kg and ethambutol 15 mg/kg) according to the World Health Organisation (WHO) tuberculosis guidelines. Within 8 weeks of intensive phase of antitubercular treatment, she had resolution of fever and joint pain.
| Discussion|| |
Tuberculosis can have various musculoskeletal manifestations like direct involvement in the form of spondylitis, septic arthritis or immunological phenomenon like erythema nodosum, reactive arthritis and uveitis. Poncet's disease is an uncommon disorder, first described by Poncet in 1897. Despite the high incidence of tuberculosis in South Asia, the occurrence of Poncet's disease is not so common, only a few case reports on this entity are available. It is considered a reactive arthritis, but differs from typical form of reactive arthritis because of its prolonged history of fever before symptoms and early resolution with antitubercular therapy. The duration of joint symptoms may vary from few days to up to 6 years. Most probable mechanism responsible is molecular mimicry between tubercular antigen and joint cartilage, resulting in an inflammatory reaction in the joint spaces.
It is a symmetrical non-destructive oligoarthritis of large joints, ankles being most common followed by knees and wrist joints. Sacroiliac joints are usually spared., Focus of tuberculosis in majority of cases is extra pulmonary, tubercular lymphadenitis being most common. Complete resolution of rheumatic symptoms within weeks and months of anti-tuberculosis confirm the diagnosis.
Erythema nodosum was present only in 8.5% of cases in a study by Rueda et al. Diagnostic criteria were proposed by Sharma et al. for Poncet's disease [Table 1]. They have suggested that initially cases should be classified as probable or possible and only after response to antitubercular treatment that they should be upgraded to definite case of Poncet' disease. As only small number of patients develops Poncet's disease despite high prevalence of tuberculosis, genetic susceptibility might play some role. Reactive arthritis has a strong association with human leukocyte antigen HLA-B27. A significantly increased frequency of HLA-B27 and DQB1*0301 alleles were found in patients of Poncet's disease in a study by Lugo-Zamudio et al.
|Table 1: Diagnostic criteria for Poncet's disease proposed by Sharma et al.|
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| Conclusion|| |
Poncet's disease should be considered in differential diagnosis of patients with prolonged fever and symmetrical large joint oligoarthritis in high tuberculosis prevalence areas and with focus of tuberculosis in body, other than joint space. It has good prognosis with resolution of symptoms with antitubercular treatment over weeks to months and no residual joint arthritis.
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| References|| |
Gupta N, Bhatnagar AK. Musculoskeletal manifestations of tuberculosis: An observational study. J Family Med Prim Care 2018;7:538-41.
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