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ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 10  |  Page : 3191-3201

Prevalence of multidrug resistance tuberculosis in adult patients in India: A systematic review and meta-analysis


1 Department of Pharmacology, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
2 Department of Pharmacology, GMERS Medical College, Himmatnagar, Gujarat, India
3 Department of Comparative Effectiveness Research, University of South Florida, Tampa, FL, USA
4 Department of Community and Family Medicine, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India
5 Department of Pharmacology, S. N. Medical College, Jodhpur, Rajasthan, India
6 Department of Paediatrics, All India Institute of Medical Sciences, Jodhpur, Rajasthan, India

Correspondence Address:
Dr. Jaykaran Charan
Department of Pharmacology, AIIMS Jodhpur, Rajasthan
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfmpc.jfmpc_542_19

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Background: Multidrug resistance tuberculosis (MDR-TB) is an important public health problem for India but there is a paucity of data related to the prevalence of MDR-TB in India. This systematic review and meta-analysis was designed to synthesize evidence regarding the prevalence of MDR-TB in adult patients in India. Methods: PubMed and Google Scholar were searched to find different observational studies reporting MDR-TB prevalence in India. Data related to MDR-TB prevalence were pooled for the analysis. PubMed was searched by using different MeSH words. Prevalence was reported with 95% confidence interval (CI). A separate analysis was done for new cases and previously treated cases. Random effect model was used and heterogeneity was assessed by I2 and Cochran Q test. Results: MDR-TB prevalence in new cases were 3% (95% CI 2%-5%, I2 = 95.3%). There was difference in prevalence between different methods of measurement of MDR-TB and study designs. MDR-TB prevalence in previously treated cases was found to be 35% (95% CI 29%-41%, I2 = 98.7%). Results vary with the method of measurement as well as the study design. Conclusion: MDR-TB prevalence in previously treated patients was found higher compared to the reported values in national surveys. There is a need for large scale cross-sectional study to verify the findings observed in this review.


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