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ORIGINAL ARTICLE
Year : 2019  |  Volume : 8  |  Issue : 5  |  Page : 1725-1729

Diagnostic efficacy of broncho-alveolar lavage carcino-embronic antigen in carcinoma of lung


1 Department of Pulmonary Medicine, V.S.S. Institute of Medical Sciences & Research, Burla, Odisha, India
2 Consultant and Intensivist, District General Hospital, Amravati, Maharashtra, India

Correspondence Address:
Dr. Sudarsan Pothal
Department of Pulmonary Medicine, V.S.S. Institute of Medical Sciences and Research, Burla, Sambalpur - 768 017, Odisha
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfmpc.jfmpc_119_19

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Context: Biomarkers can be used for screening lung cancer and the clinician can decide for further invasive workup for diagnosis. Aims: To know the diagnostic sensitivity and specificity of Carcinoembryonic antigen (CEA) in Broncho Alveolar Lavage Fluid (BALF) and serum of bronchogenic carcinoma. Settings and Design: Case-Control study was conducted in the Medical College Hospital during a period of 2 years. Methods and Material: We randomly selected 50 cases and 50 controls subjects. Cases were the patients with proven malignancy by biopsy or cytology, and controls were other non-malignant pulmonary diseases. All patients' CEA of Broncho Alveolar Lavage Fluid and serum was done. Statistical Analysis: The mean and receiver operating curve were done for CEA of serum and BAL fluid, and based on the cut-off values, sensitivity and specificity were calculated. Results: Mean value of CEA in both BALF and serum in non-smoker patients of the malignant lesion was significantly higher than the non-malignant lesion. Mean value of CEA in both BALF and serum in smoker patients of the malignant lesion was higher than the benign lesion, but statistically not significant. The cut-off value for Serum CEA is 1μg/l, whereas for BALF CEA is 2μg/l. Sensitivity, specificity of CEA of Serum and BALF combined were 92% and 62% respectively. Conclusions: Determination of CEA in the BALF and serum may be helpful as a screening tool for further workup for malignancy.


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