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Year : 2020  |  Volume : 9  |  Issue : 3  |  Page : 1749-1751

Dose-dependent L-dopa/carbidopa-induced hyponatremia presenting with hiccups

1 Department of Medicine, Iqraa International Hospital and Research Centre, Calicut, Kerala, India
2 Department of Neuropsychiatry, Iqraa International Hospital and Research Centre, Calicut, Kerala, India

Correspondence Address:
N A Uvais
Department of Psychiatry, Iqraa International Hospital and Research Centre, Calicut - 673 009, Kerala
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfmpc.jfmpc_1044_19

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Levodopa (L-dopa) is the most effective antiparkinsonian agent and is well tolerated at all stages of the disease. However, both motor and nonmotor adverse events are reported with the use of L-dopa. Electrolyte imbalances such as hyponatremia and hiccups with L-dopa/carbidopa are very rare. For the first time, we are reporting a case of L-dopa/carbidopa-induced hyponatremia and hiccup cooccurring in a 75-year-old male. He symptomatically improved after reducing the dose of levodopa/carbidopa, indicating a dose-dependent nature of these adverse events. Clinicians who prescribe L-dopa/carbidopa should be mindful of the potential for precipitating SIADH and hiccups, especially in elderly patients.

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