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REVIEW ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 7  |  Page : 3195-3199

Cardiovascular disease-related mortality risk in end stage renal disease and type 2 diabetes: A systematic review


Medical Resident in King Fahad Hospital-Al-Hofuf, Hofuf City, Eastern Province, Saudi Arabia

Correspondence Address:
Dr. Arwa A Al-Hajji
King Fahad Hospital-Al-Hofuf, Prince Fawaz St., Al-Ruqaiqah Neighborhood, Hofuf City – 31982, Eastern Province
Saudi Arabia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfmpc.jfmpc_244_20

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Background: Patients with uncontrolled type 2 diabetes can have microvascular and macrovascular complications, including renal impairment and cardiovascular diseases. However, it is unknown how diabetes and renal disease could influence cardiovascular mortality. Objective: This study aims at examining the medical literature to evaluate the risk of cardiovascular death in concomitant end stage renal disease with type 2 diabetes. Method: Medical literature was reviewed through Medline, PubMed, Embase, and Ovid database in the duration between 2009 and 2019. Searching terms included were a combination of “type 2 diabetes mellitus” AND “end-stage renal disease” AND “cardiovascular mortality”. Following this, results were filtered to include only original research articles investigating cardiovascular mortality in concomitant diabetes and end-stage renal disease. Selected trials mentioned diabetes control as well as the follow-up duration of the included patients. Result: A total of 1508 articles were retrieved. Following the exclusion of articles on animals and including only trials on humans, 32 articles appeared. A total of eight articles were identified as eligible, covering a total of 2,06,492 diabetic patients with end-stage renal disease. All the studies were prospective studies, except for three studies that were retrospective. Conclusion: There is an elevated cardiovascular mortality risk in concomitant type 2 diabetes mellitus and end-stage renal disease, especially with uncontrolled blood glucose levels.


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