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ORIGINAL ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 8  |  Page : 4305-4310

A demographic prevalence of β Thalassemia carrier and other hemoglobinopathies in adolescent of Tharu population


1 Department of Center for Advance Research (Cytogenetics Lab), King George's Medical University, Lucknow, Uttar Pradesh, India
2 Department of Pathology, King George's Medical University, Lucknow, Uttar Pradesh, India
3 Department of Clinical Hematology, King George's Medical University, Lucknow, Uttar Pradesh, India
4 Department of Obstetrics and Gynecology, King George's Medical University, Lucknow, Uttar Pradesh, India
5 Department of Prosthodontics, King George's Medical University, Lucknow, Uttar Pradesh, India
6 Department of Center for Advance Research, King George's Medical University, Lucknow, Uttar Pradesh, India
7 Department of Vice Chancellor, King George's Medical University, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Nitu Nigam
Cytogenetics Lab, Department of Center for Advance Research, King George's Medical University, Lucknow - 226 003, Uttar Pradesh
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfmpc.jfmpc_879_20

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Background and Aims: Hemoglobinopathies and thalassemias are the commonest single gene disorders in India. In Terai region of India, Hemoglobinopathies and thalassemias are the most common in the Tharu community. Therefore, in this study, we aim to evaluate the Hb variant analysis of hemoglobinopathies and thalassemias in a Tharu population in Lakhimpur Kheri Districts of Uttar Pradesh, India. Materials and Methods: Total 493 individuals were recruited in this study. The demographic details and blood samples were collected from different location at Kheri district during mega health camp. Hb variant analysis was performed by high performance liquid chromatography (HPLC) system beta thalassemia short program in BIO-RAD VARIANT. Results: Out of 493, 108 (21.9%) individual suffers with abnormal haemoglobinopathies. In which β-thalassemia trait is the commonest haemoglobinopathy (12.98%), followed by HbE trait (7.50%), and compound heterozygous HbS/β-Thalassemia trait (1.42%) in overall population. The HbF was significantly greater in HbS heterozygous (1.45 ± 1.41), whereas mean HbA2 was significantly greater in β-Thalassemia trait (5.17 ± 1.36). Conclusion: The high incidence of hemoglobinopathies and thalassemias were observed in Tharu community in Lakhimpur Kheri districts of Uttar Pradesh, Indian.


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