Journal of Family Medicine and Primary Care

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 10  |  Page : 3340--3344

Study of antibiotic efficacy of topical vancomycin powder in treatment of infected mandibular fractures and soft tissue surgical site infections


Geeta Singh1, Deepak Passi2, Deepti Daga3, Abhigyan Manas1, U Vignesh1, Sujay Milind Bhave1 
1 Department of Oral and Maxillofacial Surgery, Faculty of Dental Sciences, King Georges Medical University, Lucknow, Uttar Pradesh, India
2 Department of Dentistry, Sub-Divisional Hospital, Bundu, Ranchi, Jharkhand, India
3 Department of Head and Neck Oncology, Homi Bhabha Cancer Hospital, Varanasi, Uttar Pradesh, India

Correspondence Address:
Dr. Deepak Passi
Department of Dentistry, Sub Divisional Hospital, Bundu, Ranchi, Jharkhand
India

Aims and Objective: To study the antibiotic efficacy of topical vancomycin in infected mandibular fracture treatment and its effect in preventing surgical site infections. Materials and Methods: The study comprised of 100 subjects of infected mandibular fractures requiring open reduction and internal fixation, randomly categorized into two equal groups of 50 each, that is, vancomycin group (N = 50) treated for infected mandibular fractures with topical vancomycin powder used as adjunct and non-vancomycin group (N = 50). Clinical parameters like hospital stay, postoperative infections, postoperative fever, abnormal swelling, purulent discharge, and fistula formation at surgical site and radiographic healing was evaluated and compared between the groups. Results: Mean age of vancomycin group and non-vancomycin group was 32.5 and 33.2 years, respectively. Demographic factors of the patients like age, sex, and hospital stay (3 ± 0.5 days) did not show significant difference between two groups. Vancomycin group shows 1 hyperthermia, 2 abnormal swelling and discharge, whereas non-vancomycin group shows 6 hyperthermia, 5 postoperative abnormal swelling and discharge with statistically significant (P < 0.05). Culture sensitivity of discharged fluid shows staphylococcal + MRSA infection in two patients in vancomycin group and eight patients in non-vancomycin group. Bony healing in vancomycin group shows one patient had non-union and one had graft rejection, whereas five patients had non-union and graft rejection in non- vancomycin group. The comparative results were statistically significant (P < 0.05). Conclusion: From the result of our study we can conclude that routine use of vancomycin powder in surgical site as a surgical adjunct reduces the incidence of infections at surgical site when it is applied in addition to standard antibiotic prophylaxis. Topical application into a surgical wound also reduces the risk associated with parenteral administration of vancomycin.


How to cite this article:
Singh G, Passi D, Daga D, Manas A, Vignesh U, Bhave SM. Study of antibiotic efficacy of topical vancomycin powder in treatment of infected mandibular fractures and soft tissue surgical site infections.J Family Med Prim Care 2019;8:3340-3344


How to cite this URL:
Singh G, Passi D, Daga D, Manas A, Vignesh U, Bhave SM. Study of antibiotic efficacy of topical vancomycin powder in treatment of infected mandibular fractures and soft tissue surgical site infections. J Family Med Prim Care [serial online] 2019 [cited 2019 Dec 8 ];8:3340-3344
Available from: http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=10;spage=3340;epage=3344;aulast=Singh;type=0