Journal of Family Medicine and Primary Care

ORIGINAL ARTICLE
Year
: 2019  |  Volume : 8  |  Issue : 12  |  Page : 3925--3930

Prevalence and incidence of hyponatremia and their association with diuretic therapy: Results from North India


Abhishek Singh1, Ramesh Ahuja2, Rishi Sethi3, Akshyaya Pradhan4, Vinod Srivastava5 
1 Deparment of Internal Medicine, King George's Medical University, Lucknow, Uttar Pradesh, India
2 Department of Internal Medicine, ApolloMedics Hospital and Research Center, Lucknow, Uttar Pradesh, India
3 Deparment of Cardiology, King George's Medical University, Lucknow, Uttar Pradesh, India
4 Principal, Prasad Institute of Medical Sciences, Lucknow, Uttar Pradesh, India
5 Deparment of Internal Medicine, King George's Medical University; Department of Internal Medicine, ApolloMedics Hospital and Research Center; Deparment of Cardiology, King George's Medical University; Principal, Prasad Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Correspondence Address:
Dr. Akshyaya Pradhan
Department of Cardiology, King George's Medical University, Lucknow - 226 003, Uttar Pradesh
India

Introduction: Hyponatremia is associated with substantial morbidity and mortality. Correct estimation of their prevalence, incidence and risk factors, especially the diuretics in Indian patients is important in determining preventive strategies. Methods: This multistage mixed methods-based study was conducted in a high-volume cardiac care center to ensure the correct estimation. Patients receiving oral diuretics on an outpatient basis and those admitted to hospital for hyponatremia were enrolled. Results: The prevalence of hyponatremia was 27% while the incidence rate was 18% and 29% after 3- and 6-month of the diuretic therapy. The highest rates of hyponatremia were observed in warm season (45%, 111 in 247 patients). Multivariate logistic regression analysis revealed that low solute and nutritious intake and edematous state were negatively correlated with serum sodium levels. Neither diarrhea/vomiting nor diuretic use were found to be associated with hyponatremia. Conclusions: Diuretics use was not associated with hyponatremia in adults in this population cohort. However, elderly people on diuretics are comparatively more likely to have hyponatremia. However, a randomized parallel arm trial comparing diuretics with other antihypertensives be done to establish whether diuretics are associated with hyponatremia in this patient population.


How to cite this article:
Singh A, Ahuja R, Sethi R, Pradhan A, Srivastava V. Prevalence and incidence of hyponatremia and their association with diuretic therapy: Results from North India.J Family Med Prim Care 2019;8:3925-3930


How to cite this URL:
Singh A, Ahuja R, Sethi R, Pradhan A, Srivastava V. Prevalence and incidence of hyponatremia and their association with diuretic therapy: Results from North India. J Family Med Prim Care [serial online] 2019 [cited 2020 Sep 19 ];8:3925-3930
Available from: http://www.jfmpc.com/article.asp?issn=2249-4863;year=2019;volume=8;issue=12;spage=3925;epage=3930;aulast=Singh;type=0