Journal of Family Medicine and Primary Care

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 9  |  Issue : 1  |  Page : 287--292

Fasting and postprandial lipid parameters: A comparative evaluation of cardiovascular risk assessment in prediabetes and diabetes


Montosh Chakraborty1, Prerna Singh2, Jyothi M P Dsouza2, Karthikeyan Pethusamy3, Pandurang V Thatkar4 
1 Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Mangalagiri, India
2 Department of Biochemistry, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair, India
3 Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), New Delhi, India
4 Department of Community Medicine, Andaman and Nicobar Islands Institute of Medical Sciences, Port Blair, India

Correspondence Address:
Dr. Montosh Chakraborty
Department of Biochemistry, All India Institute of Medical Sciences (AIIMS), Mangalagiri, Present Temporary Campus, 1st Floor, Govt Siddharth Medical College, Vijayawada - 520 008, Andhra Pradesh
India

Context: Dyslipidemia plays a crucial role in atherogenesis, in both prediabetes and diabetes. There persists a lacuna in the evaluation of postprandial lipid parameters in prediabetes. Aims: To comparatively evaluate fasting and postprandial blood lipid parameters and atherogenic lipid ratios for cardiovascular risk assessment, in prediabetes and diabetes. Materials and Methods: Fifty-one patients diagnosed with diabetes mellitus and thirty-two with prediabetes were selected for the study. Lipid profile and blood glucose were analyzed in fasting and postprandial blood samples. Statistical Analysis Used: Kolmogorov–Smirnov test, Shapiro–Wilk test, one-way ANOVA, and Pearson's regression analysis were applied. Results: Postprandially, triglycerides (TG) was increased significantly in diabetes compared to controls (P < 0.01) and prediabetics (P < 0.05). Among the lipid ratios, triglyceride/high density lipoprotein (TG/HDLc) was significantly increased postprandially in diabetes compared to controls (P < 0.05). A comparative analysis of fasting and postprandial parameters within each group showed a significant increase in postprandial TG/HDLc compared to the fasting state in prediabetes (P < 0.001) and diabetes (P < 0.001). Postprandial TG (P < 0.01) and TG/HDLc (P < 0.01) showed a stronger correlation with HbA1ccompared to fasting TG (P < 0.05) and TG/HDLc (P > 0.05). The prevalence of dyslipidemia and insulin resistance was higher in postprandial state than the fasting state in prediabetes and diabetes. Conclusions: Postprandial TG and the TG/HDLc reflect lipid abnormalities than the corresponding fasting variables in diabetes and prediabetes. Postprandial TG and TG/HDLc are better reflectors of cardiovascular status in prediabetes and diabetes.


How to cite this article:
Chakraborty M, Singh P, Dsouza JM, Pethusamy K, Thatkar PV. Fasting and postprandial lipid parameters: A comparative evaluation of cardiovascular risk assessment in prediabetes and diabetes.J Family Med Prim Care 2020;9:287-292


How to cite this URL:
Chakraborty M, Singh P, Dsouza JM, Pethusamy K, Thatkar PV. Fasting and postprandial lipid parameters: A comparative evaluation of cardiovascular risk assessment in prediabetes and diabetes. J Family Med Prim Care [serial online] 2020 [cited 2020 Apr 2 ];9:287-292
Available from: http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=1;spage=287;epage=292;aulast=Chakraborty;type=0