Journal of Family Medicine and Primary Care

ORIGINAL ARTICLE
Year
: 2020  |  Volume : 9  |  Issue : 7  |  Page : 3492--3495

A study of C-reactive protein and D-dimer in patients of appendicitis


Satendra Kumar1, Jayant Maurya1, Sandip Kumar2, Shashi Kant Patne2, Amit Nandan Dhar Dwivedi3 
1 Department of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
2 Department of Pathology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India
3 Department of Radio-Diagnosis and Imaging, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh, India

Correspondence Address:
Dr. Satendra Kumar
Departments of Surgery, Institute of Medical Sciences, Banaras Hindu University, Varanasi, Uttar Pradesh
India

Background: Acute appendicitis is the most common abdominal surgical emergencies across the world. Objective: The aim of this study was to determine the value of C-reactive protein (CRP) and D-dimer as diagnostic markers of acute appendicitis. Study Design: It was a Prospective observational clinical study. Method: The present study was carried out in General Surgical Unit of University Hospital, Institute of Medical Sciences, Banaras Hindu University, Varanasi from September 2015 to July 2017. All data including patient's demography, clinical examination, laboratory test results, and appendix histology were summarized. Receiver operating characteristic (ROC) curve of TLC, CRP, and D-dimer was analyzed. Results: Total 65 patients who presented with periumbilical pain or pain in right iliac fossa (RIF) were included in the study. The mean age of the patients was 31.18 ± 14.59 years (range: 15 to 65 years) with male : female ratio was 2.21:1. The most common symptom was pain in right iliac fossa (100%) followed by nausea/vomiting (69.2%). The mean leucocyte count, CRP, and D-dimer levels were significantly raised in appendicitis group as compared to negative appendicectomy group (P = 0.025, P = 0.036, and P = 0.025, respectively). The receiver operating characteristic (ROC) curve for TLC was not helpful for differentiating between appendicitis and negative appendicitis (P = 0.073). In addition, D-dimer was helpful for differentiating between appendicitis and negative appendicitis (P = 0.002). However, CRP was also found to be helpful for differentiating between appendicitis and negative appendicitis (P = 0.030). Conclusion: The diagnosis of appendicitis remains multifactorial and biochemical markers like CRP and D-dimer may help to guide the surgeon in the decision making.


How to cite this article:
Kumar S, Maurya J, Kumar S, Patne SK, Dwivedi AN. A study of C-reactive protein and D-dimer in patients of appendicitis.J Family Med Prim Care 2020;9:3492-3495


How to cite this URL:
Kumar S, Maurya J, Kumar S, Patne SK, Dwivedi AN. A study of C-reactive protein and D-dimer in patients of appendicitis. J Family Med Prim Care [serial online] 2020 [cited 2020 Sep 29 ];9:3492-3495
Available from: http://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=7;spage=3492;epage=3495;aulast=Kumar;type=0