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 Table of Contents 
Year : 2017  |  Volume : 6  |  Issue : 1  |  Page : 11-18  

Diabetes and Ramadan: A concise and practical update

1 Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire, UK
2 Department of Pathology, Faculty of Medicine and Health Sciences, Omdurman Islamic University, Khartoum, Sudan
3 Department of Pathology, Faculty of Medicine and Health Sciences, Nile Valley University, Atbara, Sudan
4 Department of Medicine, Faculty of Medicine and Health Sciences, Nile Valley University, Atbara, Sudan
5 Department of Surgery, Whiston Hospital, Merseyside, UK
6 Department of Pathology, Faculty of Medicine, University of Medical Sciences and Technology, Khartoum, Sudan

Date of Web Publication18-Sep-2017

Correspondence Address:
Mohamed H Ahmed
Department of Medicine and HIV Metabolic Clinic, Milton Keynes University Hospital NHS Foundation Trust, Eaglestone, Milton Keynes, Buckinghamshire
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2249-4863.214964

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Despite the fact that the month of Ramadan includes 29–30 days and the duration of fasting for each day can last for between 12 and 16 h, it was estimated that a large number of individuals with diabetes do fast during Ramadan. In light of recent advancement of new pharmacological agents, drugs such as vildagliptin, sitagliptin, and liraglutide were found to be safe to use during this month of fasting. These therapeutic agents can also be used in combination with metformin. The use of sulfonylureas, in most of the recent guidelines about diabetes and Ramadan, seems not to gain much support due to the risk of hypoglycemia. In this review, we also addressed the use of insulin injection, insulin pump, and education before, during, and after Ramadan. Further research is needed to determine (i) the therapeutic benefit of new antidiabetic agents and (ii) the benefit of new technologies for the treatment of diabetes.

Keywords: Diabetes, fasting, Ramadan

How to cite this article:
Ahmed MH, Husain NE, Elmadhoun WM, Noor SK, Khalil AA, Almobarak AO. Diabetes and Ramadan: A concise and practical update. J Family Med Prim Care 2017;6:11-8

How to cite this URL:
Ahmed MH, Husain NE, Elmadhoun WM, Noor SK, Khalil AA, Almobarak AO. Diabetes and Ramadan: A concise and practical update. J Family Med Prim Care [serial online] 2017 [cited 2021 Aug 3];6:11-8. Available from: https://www.jfmpc.com/text.asp?2017/6/1/11/214964

  Introduction Top

The month of Ramadan is a special occasion for all Muslims worldwide as it is the month of fasting. During fasting, Muslims abstain from all sort of oral intakes including medication. The duration of fasting starts before the beginning of dawn and ends with dusk, and this would explain the difference in hours of fasting in different parts of the world. Importantly, it was estimated that around 79% of individuals with type 2 diabetes are likely to fast.[1] It is important to mention that the Quran has made a clear exemption for the sick, elderly, travelers, children, expectant, and breastfeeding mothers not to fast during Ramadan.[2]

Due to the complexity of the management of diabetes during Ramadan, the understanding of the pathophysiology of fasting with diabetes is important for the treating physician.[3] The main concerns in fasting are hypoglycemia, hyperglycemia, dehydration, and ketoacidosis. Therefore, education about physical activity, food consumption, and medication adjustment is crucial to guard against complications. Before addressing the issues of treatment and patient education, we provide a comprehensive review of the major biochemical and physiological changes associated with fasting.

  Biochemical and Physiological Changes during Fasting Top

Several studies have shown that fasting is associated with significant changes in the biochemical parameters among individuals with diabetes. For example, among 1301 participants with diabetes in one study, HbA1c, lipid profile, arterial blood pressure, and uric acid were significantly lower during Ramadan as compared to other periods of the year. One may conclude from the above that fasting may, in fact, be beneficial for the health of some individuals with diabetes.[4]

Interestingly, no marked changes were observed in the mean glucose level, episodes of hypoglycemia, and mean glycemic excursion changes when continuous glucose monitoring among individuals with diabetes during Ramadan was applied.[5] Furthermore, fasting in individuals with diabetes was shown to have improved leptin, adiponectin, and insulin sensitivity.[6],[7],[8],[9] Inflammatory markers were also shown to have diminished with plasma homocysteine, D-dimer level, C-reactive protein, interleukin-6, and fibrinogen being reduced during fasting.[10],[11] The improvement in cardiovascular and inflammatory markers may be in part attributed to decrease total calorie intake and, hence, weight reduction.[12],[13],[14] The incidence of significant hypoglycemia and hyperglycemia in Type 2 diabetics is low as demonstrated in the study that continuously monitored blood glucose levels in Type 2-affected individuals.[14] However, any individuals with diabetes should be educated to remain vigilant for these complications.

Ramadan is considered a month of celebration for many Muslims globally. It is with this state of ecstasy that the month carries the paradoxical risk of food excess after the hours of fasting. This is of particular importance to those individuals with fasting with diabetes.[15] Therefore, its not surprising that excess intake of fat and carbohydrate during the night coupled with the decreased physical activity during the day were found to be associated with weight gain during Ramadan.[16] [Table 1] displays the physiological and biochemical changes associated with fasting.
Table 1: Summary of the biochemical and physiological changes associated with Ramadan fasting

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Understanding the physiological and biochemical changes associated with fasting Ramadan allows a better understanding of the management approaches and application of new therapeutic agents.

  Patient Education before, during, and after Ramadan Top

The purpose of patient education, clinical evaluation, and open reflections is, thus, to ensure patient's safety while fasting.[31],[32],[33] It is important to emphasize that dietary counseling and education of patients are associated with a significant reduction of acute complications.[34] For instance, the impact of individualized education before Ramadan was evaluated in individuals with Type 2 diabetes (774 individuals, from Egypt, Iran, Jordan, and Saudi Arabia). In this study, 67% received an individualized education (about nutrition, physical activity, drug adjustment, and glucose monitoring) and 33% received usual care. It was concluded that this particular study showed that individualized education improved safety during Ramadan in terms of decreasing hypoglycemic events, improved diabetes control, and prompted weight loss.[35] Interestingly, in a small pilot study, telemonitoring was also shown to be of potential benefit in decreasing metabolic complications associated with Ramadan fasting, particularly hypoglycemia.[36] The physician can also educate patient about that exemption from fasting is possible in case fasting will worsen the health of the individuals and this in-line with Islamic Fiqh (Islamic jurisprudence).[37] Therefore, patient education is very important to achieve safe fasting and health-care providers are required to pass necessary information (guidelines, leaflets translated into different languages, and use of telemedicine).[38],[39] Involvement of all health practitioners may be another mean of providing safe education. For instance, pharmacists well trained about the management of diabetes during Ramadan may also contribute to patient education, especially in heavily populated or remote areas.[40] An integrated approach addressing the management of Type 1 and Type 2 diabetes is provided in [Table 2].
Table 2: Summary of management of both Type 1 and 2 diabetes during Ramadan

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The International Group for Diabetes and Ramadan recommended (2015 guidelines) that Taraweeh prayers should be regarded as a physical exercise with the potential to induce dehydration and hypoglycemia.[41] The Taraweeh prayers are long night prayers that last for 1–2 h and are performed during each day of the entire month of Ramadan. Therefore, individuals with diabetes are advised to drink plenty of water and to guard against hypoglycemia. Dates, a customary fruit that Muslims break their fast with, are regarded as having a low glycemic index and may result in possible improvement of glucose and lipid profile and possible reduction in cardiovascular risk factors.[42],[43],[44],[45] It is important that physicians should advise individuals with diabetes about the risk of developing hyperglycemia after Ramadan. Ramadan is followed by a 3-day festival known as Eid al-Fitr. This festival is usually celebrated with sweets and gifts and the potential for high calorific intake. It is, therefore, important that physicians should also emphasize the importance of resuming medications as normal and not in reduced doses.

Type 2 diabetes

The main concern with therapeutic agents during Ramadan was hypoglycemia.[12],[13],[14] Therefore, individualized education and medication adjustment are crucial to ensure safe fasting.[37] In the following discussion, we have included tables that provide a quick summary of medications and related studies, while in the text, we have provided the general consensus about whether to use or not to use these medications during Ramadan. [Table 3] provides a list of studies about the use of sulfonylureas, biguanides, alpha-glucosidase inhibitors, thiazolidinediones, and meglitinides while [Table 4] provides a list of studies about the use of incretins and glucagon-like peptide-1 (GLP-1) agonists.
Table 3: Summary of studies about the use of sulfonylureas, biguanide, alpha-glucosidase inhibitors, thiazolidinediones, and meglitinides during the fasting month of Ramadan

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Table 4: The recent therapeutic agents introduced for treatment of Type 2 diabetes

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  General Consensus about Therapeutic Agents during Ramadan Top

We have included this guide consensus reached by the International Group for Diabetes and Ramadan published periodically in 2005, 2010, and 2015.[1],[16],[41] We have also included recommendations from the South Asian Consensus Guidelines published in 2012.[66] In addition, we also searched MEDLINE for clinical trials during Ramadan, clinical reviews, and systemic reviews. For ease of reading, we have summarized the majority of these studies in the [Table 2],[Table 3],[Table 4] and only included general consensus in the following discussion.


Due to the risk of hypoglycemia associated with sulfonylureas, some guidelines did not recommend them and others suggested to use them with caution during Ramadan. The only sulfonylurea associated with a minimum risk of hypoglycemia is gliclazide.


There is general agreement in all published studies that metformin can be safely used during Ramadan; however, dose reduction is needed [Table 2].


Despite the low incidence of hypoglycemia with glitazones during Ramadan, their use is not widely recommended due to their side effects, for example, water retention, risk of heart failure, and weight gain.


Meglitinides are safe to be used during Ramadan, and there is no risk of hypoglycemia.

Alpha-glucosidase inhibitors

Hypoglycemia is not a serious issue but is limited use due to gastrointestinal side effects. There were no randomized clinical trials available.

Dipeptidyl peptidase-4 inhibitors

There is general agreement that vildagliptin or sitagliptin as monotherapy is safe during fasting. They can be added to metformin and very low risk of hypoglycemia.

Glucagon-like peptide-1 mimetics

Due to the absence of hypoglycemia associated with the injection of exenatide and liraglutide, they can have a potential for safe use during Ramadan. In a randomized controlled trial, liraglutide in comparison to sulfonylurea is well tolerated during Ramadan and may be an effective therapy in combination with metformin in achieving glycemic control, with low risk of hypoglycemia and adequate weight loss.[65] It is plausible to suggest that emerging evidence supports the use of GLP-1 receptor agonists during fasting, albeit further evidence is needed.

Insulin and type 2 diabetes

The administration of long-acting insulin and mixed insulin is shown to be safe in individuals with Type 2 diabetes. For instance, premixed insulin (25% insulin lispro and 75% neutral protamine lispro) can be given with the sunset meal and half the usual evening dose to be used with the predawn meal (suhoor).[67],[68] Long-acting insulin-like glargine can be given as a single injection and this can be administered with short-acting insulin or metformin.[69]

Type 1 diabetes

Due to the high risk of hypoglycemia, hyperglycemia, and diabetic ketoacidosis, individuals with Type 1 diabetes may find fasting challenging, especially those with poor diabetes control and comorbidities.[1],[12] Long-acting insulin use such as glargine is associated with fewer episodes of hypoglycemia, and the use of basal bolus regimen is preferred as compared with the conventional twice daily insulin regimen.[68],[69],[70] However, studies have shown that NovoMix insulin has been used in Ramadan with some success. For instance, 100% of the pre-Ramadan dose of 70/30 mix insulin corresponding with the sunset meal (iftar) and 50% at a predawn meal would produce good results.[41] Furthermore, the use of 70% of intermediate-acting insulin and 30% of short-acting insulin with two meals is also shown to be safe and episodes of serious hypoglycemia or ketoacidosis were observed.[71],[72] Further research is needed to evaluate the safety of insulin pump during fasting.[73]

Insulin pump

Several studies have shown the potential benefit of insulin pump during the fasting month. In adolescents with Type 1 diabetes, the use of subcutaneous insulin infusion (continuous subcutaneous insulin infusion) was associated with less hypoglycemia and improvement in diabetes control.[74] Interestingly, case series studies in adolescents and adults with Type 1 diabetes mellitus receiving insulin pump therapy during fasting showed fewer hypoglycemia episodes and adequate glycemic control.[75] The use of highly advanced insulin pumps or artificial pancreas may provide an excellent opportunity for individuals with diabetes to fast without the risk of hypoglycemia. For instance, the new MiniMed 640G insulin pump is designed to sense hypoglycemia before it occurs and suspends insulin infusion delivery immediately. Less advanced pump such as Medtronic insulin pump, which stops insulin infusion when prespecified sensor glucose threshold is reached, has shown potential benefit. For instance, in a study of 49 patients fasted, the use of insulin pump was associated with less severe hypoglycemia and average diabetes control, no deterioration in diabetes control.[76] In a prospective observational, single-center study, the use of insulin pump was not associated with a change in insulin administrated, no major hypoglycemia event, and stable glycemic control.[77] Due to high cost, an insulin pump is not widely used.

  New Pharmacological Agents for Diabetes and Their Potential Role during Ramadan Fasting Top

Within the last 5 years, several pharmacological agents for the treatment of diabetes were discovered. Importantly, the main potential benefits of all these medications are a lower risk of hypoglycemia (insulin glargine 300, inhaled insulin - Afrezza, SGLT2 inhibitors, insulin degludec, and IDegLira [insulin degludec + liraglutide]). Therefore, we recommend that clinical studies in the future may reveal which of these medications can be safely used during Ramadan fasting.

  Pregnancy, Diabetes, and Fasting Top

Currently, there is no scientific evidence to recommend fasting for pregnant women with diabetes. The Islamic Holy texts also exempt pregnant and lactating women from fasting.

  Conclusion Top

In recent years, numerous studies about diabetes and Ramadan fasting were published. The dipeptidyl peptidase-4 inhibitors such as sitagliptin and vildagliptin are associated with less risk of hypoglycemia without significant hyperglycemia during Ramadan. In addition, these agents can also be safely used alongside metformin. The use of sulfonylureas is not widely endorsed in the recent guidelines due to the risk of hypoglycemia. The use of liraglutide is so far appeared to be potentially safe therapy during Ramadan, but as yet there is one study about using liraglutide during Ramadan. Administration of the long-acting insulin such as glargine has shown potential benefit in selected patients with diabetes. An insulin pump can potentially enhance patients' chances to fast Ramadan without significant risks. There are still a lot of unanswered questions about the new therapeutic treatments for diabetes and Ramadan; therefore, further research is needed to evaluate the therapeutic benefit of these agents.


We are thankful to our families and children during the time of preparation of this review. We are also indebted to authors of articles that we cited in this study.

Financial support and sponsorship

Patients Helping Fund-Khartoum, Sudan.

Conflicts of interest

There are no conflicts of interest.

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  [Table 1], [Table 2], [Table 3], [Table 4]

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