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Year : 2020  |  Volume : 9  |  Issue : 1  |  Page : 31-35

Vogt–Koyanagi–Harada (VKH) syndrome: A new perspective for healthcare professionals

1 Department of Public Health Dentistry, Tatyasaheb Kore Dental College and Research Centre, Kolhapur, Maharashtra, India
2 BDS, Private Practitioner, Chandravardai Nagar, Ajmer, Rajasthan, India
3 Department of Oral and Maxillofacial Pathology, Hi-Tech Dental College and Hospital, Bhubaneswar, India
4 Department of Oral and Maxillofacial Pathology, Institute of Dental Sciences, Sehora, Jammu & Kashmir, India
5 BDS, Private Practitioner, CDA, Somerset, New Jersey
6 Department of Oral and Maxillofacial Pathology, Surendera Dental College and Research Institute, Rajasthan, India
7 Private Practitioner, New Delhi, India

Correspondence Address:
Dr. Sonika Sharma
Private Practitioner, New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfmpc.jfmpc_787_19

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Vogt–Koyanagi–Harada syndrome (VKH syndrome) is a rare granulomatous inflammatory disease that affects the melanin pigment producing melanocytes and mainly affects the pigmented structures such as eyes, ear, skin, meninges, and hair. VKT is an autoimmune disorder, which is mainly a T CD4+ Th1 lymphocyte–mediated aggression to melanocytes, in individuals with a genetic predisposition, in particular, the presence of HLA-DRB1 * 0405 allele. Melanin usually gives color to skin, hair, and eyes. Melanin is also found in the retina, where it plays a role in normal vision. This disease mainly leads to vision and hearing disturbances, followed by dermal problems. The most common symptoms include vitiligo, headaches, hair loss (alopecia), and hearing loss. This article describes the various signs and symptoms of VKH disease and its pathogenesis.

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