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Year : 2020  |  Volume : 9  |  Issue : 5  |  Page : 2531-2534

Triple A syndrome (Allgrove syndrome) – A journey from clinical symptoms to a syndrome

Department of Medicine, All India Institutes of Medical Sciences, Jodhpur, Rajasthan, India

Correspondence Address:
Dr. Deepak Kumar
Room No. B36, OPD Block Ground Floor, Department of Medicine, All India Institutes of Medical Sciences Jodhpur, Rajasthan
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfmpc.jfmpc_237_20

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Triple A syndrome (Allgrove syndrome) is characterized by a triad of specific features, namely, alacrimia, adrenal insufficiency, and achalasia cardia. It is a rare autosomal recessive disorder. In the present study, an 18-year-old boy was presented with complaints of decreased tears, darkening of the skin, difficulty in walking and standing up from sitting position, and difficulty in swallowing liquids. Adrenal insufficiency, alacrimia, achalasia, and neurological manifestations were confirmed with relevant laboratory investigations. His condition improved with steroids and artificial teardrops. However, a vigilant eye of the clinician for clinical clues of syndromic manifestation will help in early diagnosis and proper management.

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