Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 3996
Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
ORIGINAL ARTICLE
Year : 2020  |  Volume : 9  |  Issue : 8  |  Page : 3986-3990

Clinical indicators to define etiology in patients with primary amenorrhea: Lessons from a decade of experience


1 Department of Obstetrics and Gynecology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
2 Department of Endocrinology, Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh, India
3 Department of Obstetrics and Gynecology, All India Institute of Medical Sciences (AIIMS), New Delhi, India

Correspondence Address:
Dr. Rama Walia
Room Number 10, Ground Floor, Nehru Hospital Extension Block, Postgraduate Institute of Medical Education and Research, Chandigarh - 160012
India
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfmpc.jfmpc_85_20

Rights and Permissions

Context: Primary Amenorrhea is worrisome for the adolescent as well as their guardian. It is essential to be able to identify the underlying pathology and initiate appropriate management strategies, well in time. Aims: To study the clinical features, with an aim to identify discriminatory clinical features to indicate a most probable diagnosis. Design: A prospective, observational study. Setting: The Gynecologic Endocrinology Clinic of Department of Obstetrics and Gynecology and Endocrinology Outpatient Department of a tertiary centre in North India. Methodology: In total 328 women with primary amenorrhea, registered during a duration of 10 years (January 2008 to December 2017), were enrolled for the study and a proforma was filled with their medical details. Results: It was observed that patients with normal stature and underdeveloped breasts were likely to be hypogonadotropic hypogonadism, whereas those with short stature and underdeveloped breasts were more likely to be gonadal failure with underlying chromosomal abnormality. The three most common causes of primary amenorrhea in the index population were hypogonadotropic hypogonadism (117/328 = 35.1%), gonadal dysgenesis (99/328 = 30.2%) and mullerian agenesis (53/328 = 16.2%). Conclusion: Age, height, and Tanner staging at presentation can provide a clue toward diagnosis, even before confirmatory tests are available. One of the largest studies reported on primary amenorrhea, we found hypogonadotropic hypogonadism to be the commonest cause, in contrast to previous studies.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed170    
    Printed4    
    Emailed0    
    PDF Downloaded34    
    Comments [Add]    

Recommend this journal