|Year : 2020 | Volume
| Issue : 8 | Page : 4437-4440
Death from rabies: The reason being poor compliance to vaccination or it's failure
Shyam Kishor Kumar1, Pratima Gupta1, Prasan Kumar Panda2
1 Department of Microbiology, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India
2 Department of Medicine, All India Institute of Medical Sciences (AIIMS), Rishikesh, Uttarakhand, India
|Date of Submission||19-Apr-2020|
|Date of Decision||10-Jun-2020|
|Date of Acceptance||25-Jun-2020|
|Date of Web Publication||25-Aug-2020|
Dr. Prasan Kumar Panda
Department of Medicine, Fifth Floor, College Block, All India Institute of Medical Sciences (AIIMS), Rishikesh - 249203, Uttarakhand
Source of Support: None, Conflict of Interest: None
Rabies is endemic in India and responsible for 20,000 human deaths every year. It is 100% preventable when the vaccine is taken along with proper wound care and rabies immunoglobulin administration though update continues regarding the requirement of the number of vaccine doses, the need for immunoglobulin, and if required their types. We study four cases of rabies having street dogs' bite category grade 3. Everyone took vaccines at least three doses but none of them took rabies immunoglobulin. They developed symptoms of rabies with a gap of 15–28 days after the bites and admitted to a tertiary care center. One patient was left against medical advice and three patients were treated according to the modified Milwaukee protocol. But, none of them could be saved. So, it may be proposed that the reason of deaths may be due to lack of administration of rabies immunoglobulin (passive vaccination) or failure of vaccines. Hence, the government may focus on the administration of complete and quality post-exposure prophylaxis in all cases of animal bites. Although Milwaukee protocol saves few lives, it may be further improved or other treatment modalities may be developed for rabies treatment.
Keywords: Dog bite, Milwaukee protocol, post-exposure prophylaxis, rabies immunoglobulin
|How to cite this article:|
Kumar SK, Gupta P, Panda PK. Death from rabies: The reason being poor compliance to vaccination or it's failure. J Family Med Prim Care 2020;9:4437-40
|How to cite this URL:|
Kumar SK, Gupta P, Panda PK. Death from rabies: The reason being poor compliance to vaccination or it's failure. J Family Med Prim Care [serial online] 2020 [cited 2021 Apr 10];9:4437-40. Available from: https://www.jfmpc.com/text.asp?2020/9/8/4437/293067
| Introduction|| |
Rabies is endemic in India responsible for 20,000 human deaths every year. The dog is responsible for 99% of human cases in endemic regions. There is no effective treatment to date. A treatment modality named the Milwaukee Protocol is hope but could not succeed much. Vaccine is available which is 100% effective if taken properly. Some studies have reported deaths due to deviation from WHO guidelines of post-exposure prophylaxis (PEP) which is expected. And some studies have reported true failure that is, patients develop rabies despite appropriate PEP. But this is not expected. Hence it is difficult to say whether incomplete vaccination or vaccine failure is the cause of rabies in recent times.
Thereby, we report a case series of four recent rabies deaths despite the initiation of at least three doses of vaccines (active immunity) reflecting possible vaccine failure or rarely due to lack of RIG administration.
| Case Presentation|| |
We received four cases of rabies last year. The demography, clinical details, laboratory findings, treatment, and outcomes were described in [Table 1].
|Table 1: The demography, clinical, laboratory, treatment, and outcome details of four rabies patients|
Click here to view
All of them had a history of dog bites in the last 15–28 days. Two patients were bitten in the upper part of the body (face and hand), while the other two were bitten in lower limbs. All had received 3–5 doses of vaccines, none received rabies immunoglobulins. Out of four patients, one patient had a paralytic form of rabies and the other three had encephalitis form, suggested with MRI brain and spine and confirmed with paired rising CSF antibody titers or positive RNA [Table 1].
All patients were managed in an isolation ward with ventilator support, barrier nursing, and strict standard precautions. Modified Milwaukee protocol (since haloperidol, various laboratory monitoring, and regular virological monitoring were not followed and methylprednisolone pulse therapy was administered as per our neurologist consultation contrast to original protocol) was followed in three cases. All were died in due course of time either at the hospital or home after telephonic confirmation [Table 1].
| Discussion|| |
We report four vaccinated rabies deaths who did not receive rabies immunoglobulins (RIG). These cases may entail incompleteness or failure of vaccination.
Proper wound washing with soap and water can prevent rabies cases in one-third of cases. Poor and illiterate persons are not aware of this step. Probably, none of our cases would wash their wound properly which would contribute to death.
RIG administration is a very crucial step for preventing rabies. Rabies vaccines induce antibody response only after 7–14 days of a PEP regimen. Immediate administration of RIG at the bite site slows down or stops viral progression and increases patient survival. Gadekar et al. reported two patients bitten by same rabid dog. Both patients had a Grade 3 bite. One patient properly followed the vaccination guidelines and got completely cured. Another patient took a vaccine but without wound cleaning and RIG and developed rabies. Some other studies also point towards improper or non-administration of RIG., So, lack of immunoglobulin administration was probably the reason for vaccine failure in all of our cases. However, the WHO 2018 vaccine position paper stated that wound washing and complete PEP vaccine can prevent rabies in more than 99% cases even in absence of RIG. Changalucha J et al. also mentioned 473 cases who escaped rabies after receiving PEP (at least 3 vaccines completed) without RIG. If this is true, then our cases died not because of a lack of RIG administration but may be of other cause.
However, true failures without recognized defects in PEP management have also been reported. A case report was published in the newspaper “Hindustan Times” (17 April 2015) that revealed a girl with grade 3 bite received appropriate wound care, RIG, and Rabipur vaccine within 10–12 hours of the bite. But, she developed rabies and died. Wilde et al. reported 15 rabies cases. Seven cases developed rabies due to errors in management. But, eight cases developed rabies despite receiving appropriate PEP, though, these had bite sites on highly innervated zone like face or hands or multiple bite sites. Hence these suggest the possibility of true failure of vaccines. The same thing could have happened in our four cases.
Adherence to PEP vaccination and immunoglobulin in India is very low, 20.9%, and 1.3% respectively as described by Sudarshan et al. Higher cost and non-availability of RIG at health care centers are two limiting factors. The cost of equine RIG (eRIG) and human RIG (hRIG) in India, for an average patient of 60 kg bodyweight, are approximately US $20 and the US $500 respectively which are very costly for the general population of India. Bharti et al. proposed an alternative method—all the bite sites infiltration with RIG, but not according to body weight. So, the remaining amount may be available for other patients. It is more economic as well as to make availability of RIG even in short supply. Based on a study in BHK 21 cells & Swiss albino mice, Madhusudana et al. found that the dose of RIG can be minimized by at least 16 times than the presently used dose. But, it needs further optimization in human beings. Mass dog vaccination is another approach that can be helpful for the containment of rabies. If 70% of dog vaccination would be implemented under the annual pulse vaccination program over several years, rabies could be eliminated from dogs. This step is taken in different countries of Africa, Asia, Europe, and America. Government of India may provide RIG free of cost to general people similar to the government of Tunisia or open “Bite treatment center” in endemic zones as in Philippines.,
There is a tenet “If a patient has rabies, he will die in the next few days; if he does not die, he does not have rabies!” There are only 29 reported cases of rabies survivors worldwide to date., In our study, cases 1, 2, and 4 were managed according to the modified Milwaukee protocol. Case 1 and 4 failed but case 2 was showing some signs of improvement (volume control ventilation reduced to pressure support ventilation and GCS-E1VtM1 to GCS-E3VtM1) but got LAMA before we could derive any conclusion. High-quality intensive care support may give more motivation to researchers to unravel the mechanisms to defeat the rabies infection.
| Conclusions|| |
- All patients must receive RIG in category 3 animal bites. Dose optimization may be done to be more economic.
- The government may try to provide free RIG for all or establish a “Bite treatment center” in highly endemic zones.
- Vaccine failure may be one of the concerns for rabies deaths where patients received at least 3 doses. So, there should be updated quality validation in available vaccinations. We should also think of a new strain of the virus.
- Newer treatment strategies and effective anti-rabies medications need to be explored.
We have obtained ethical clearance and waiving of consent from the institute.
Financial support and sponsorship
Conflicts of interest
There are no conflicts of interest.
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