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Year : 2020  |  Volume : 9  |  Issue : 8  |  Page : 4456-4459

An unusual association of Morning Glory Syndrome with chronic myeloid leukemia-Philadelphia chromosome

Department of Ophthalmology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand, India

Correspondence Address:
Dr. Anupam Singh
Department of Ophthalmology, All India Institute of Medical Sciences, Rishikesh, Uttarakhand - 249 203
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jfmpc.jfmpc_892_20

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Morning glory disc anomaly (MGDA) is a rare congenital malformation that results from the incomplete formation of the optic nerve in utero. The majority of the patients have unilateral involvement and poor vision leading to sensory strabismus. Morning Glory Syndrome (MGS) may be a part of other syndromes and systemic abnormalities like transsphenoidal basal encephalocele, midfacial malformations, absent optic chiasma, MoyaMoya syndrome, and renal agenesis. In the present report, we describe a patient with a large disc with an excavated posterior scleral opening with a white glial tuft at the centre. The blood vessels were increased in number and arranged radially from the disc with peripapillary hyperpigmentation in clumps. Funnel-shaped excavation of the posterior globe was also noted on MRI. Associated ocular features were microcornea, nystagmus, esotropia, and systemic features included chronic myeloid leukemia- Philadelphia chromosome (CML-PC) and empty sella turcica. We report an unusual association of MGS with CML-PC.

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