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 Table of Contents 
REVIEW ARTICLE
Year : 2021  |  Volume : 10  |  Issue : 1  |  Page : 41-47  

Dental practice in the era of COVID-19: A review of literature


1 Department of Oral and Maxillofacial Surgery, School of Dentistry; Craniomaxillofacial Research Center, Tehran University of Medical Sciences, Tehran, Iran
2 Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, International Campus, Tehran, Iran

Date of Submission28-May-2020
Date of Decision31-Aug-2020
Date of Acceptance25-Oct-2020
Date of Web Publication30-Jan-2021

Correspondence Address:
Dr. Mina Khayamzadeh
Department of Oral and Maxillofacial Medicine, School of Dentistry, Tehran University of Medical Sciences, International Campus, Mahan Street, Khani Abad, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/jfmpc.jfmpc_1008_20

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  Abstract 


Dental practitioners confront the highest risk of COVID-19 infection due to constant exposure to saliva, droplets, blood, and aerosols. Despite the suspension of routine dental care in many countries around the world, dental professionals perceive a moral duty to take part in the global fight against the pandemic. Therefore, dental professionals should be vigilant in defending against the transmission of the virus and as well as in the diagnosis of the disease through the oral manifestations of it. We conducted a literature review on publicly available data to outline updates on guidelines and studies of dental settings during the COVID-19 era. In this literature review, the categorization of the patients for dental treatments, protective precautions for the dental practice, considerations for dental drug prescription, and oral manifestations of the disease has been reviewed.

Keywords: Coronavirus, COVID-19, SARS-CoV-2, dentistry, pandemic


How to cite this article:
Razmara F, Khayamzadeh M, Shabankare G. Dental practice in the era of COVID-19: A review of literature. J Family Med Prim Care 2021;10:41-7

How to cite this URL:
Razmara F, Khayamzadeh M, Shabankare G. Dental practice in the era of COVID-19: A review of literature. J Family Med Prim Care [serial online] 2021 [cited 2021 Feb 25];10:41-7. Available from: https://www.jfmpc.com/text.asp?2021/10/1/41/307866




  Introduction Top


In December 2019, Wuhan Health Commission of Hubei province of the Republic of China reported an array of 27 patients with pneumonia of obscure etiology, presenting with a constellation of symptoms such as fever, nonproductive cough, dyspnea, and bilateral ground-glass opacities with patchy shadows in computed tomography of the lungs. The patients were epidemiologically traced back into Huanan Seafood Wholesale Market, trading live species of bats, pangolins, snakes, and badgers which bolstered the hypothesis that a live animal had been the intermediary of transmitting a pathogen to the patients.[1],[2] The bronchoalveolar lavage fluid of three Wuhan patients, revealed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as the causal factor of the disease.[3] The violent and rapid propagation of the virus through unknown mechanisms and due to population density and proximity of the live animal marketplaces made Wuhan the provenance of the animal-human interface and led to a critical juncture at which the World Health Organization declared the pandemic of coronavirus disease 2019 (COVID-19) on February 2020.[4]

The CoVs family is a class of enveloped positive-sense, single-stranded RNA viruses that are genotypically and serologically divided into four subfamilies of α, β, γ, and δ-CoVs among which α- and β-CoVs are responsible for human infections, causing respiratory, hepatic, enteric, and neurologic diseases.[5] SARS-CoV-2 as a β-CoV is evolved into two major types of L and S. It has been suggested that the S type depicts a more aggressive behavior and quicker spread whereas the L type is considered to have a relatively milder nature.[3] Human angiotensin-converting enzyme2 (ACE2) is the main host receptor of COVID-19 infection which is broadly expressed in the oral and nasal mucosa, esophagus, bronchus, lung, heart, kidney, intestinal cells, bladder, activated leukocytes, and testicular tissues, resulting in the vulnerability to multiple organ damage.[6] Among the myriad of organ involvements of COVID-19 infection, the mucosal epithelium of the upper respiratory tract is the primary site of viral replication which may proceed in the lower respiratory tract and gastrointestinal mucosa that can either lead to a mild, asymptomatic viremia or a cytokine storm initiated by the downregulation of ACE2. The latter precipitates the Acute Respiratory Distress Syndrome (ARDS) that stands out as the preeminent cause of death among COVID-19 patients.[5]

The rapid and disruptive diffusion of COVID-19 is probably associated with the easy transmission routes of the virus through respiratory droplets and contact transmission. Although primary concern has aimed attention to near-field transmissions such as hand-to-face transport from contaminated surfaces or person-to-person transmission through coughing/sneezing, recent studies are suggestive of other possible transmission routes such as aerosols, fecal-oral, and vertical transmission from mother to baby.[7],[8]

In terms of the exposure risk for various working categories, dental practitioners confront the highest risk of COVID-19 infection due to constant exposure to saliva, droplets, blood, and aerosols. Therefore, inhalation of infected droplets/aerosols and direct contact with contaminated instruments or surfaces puts both dental practitioners and patients at stake.[8] Moreover, all the patients seeking dental care in the era of COVID-19 pandemic should nevertheless be considered infected regardless of the nonappearance of common clinical manifestations of the disease. The majority of the COVID-19 infected patients are either asymptomatic or represent with self-limiting, mild to medium symptoms who can be easily misinterpreted as healthy individuals.[9] Dental practitioners can also play a pivotal role in careful assessment of the patients in terms of their health status through which high-risk patients can be detected and a contagion-reduced treatment can be implemented for patients with unknown risk in emergency conditions.[8]

Concerning the aforementioned evidence, the contributory role of dentistry in the detection and assessment of initial symptoms of COVID-19 infection and providing emergency patients with a contagion-reduced environment is indisputable in the era of this pandemic outbreak. In this article, we aimed to review the challenges and perspectives of dentistry and oral and maxillofacial surgery in the upheaval of COVID-19 in terms of patient categorization for dental treatments, protective precautions in dental practice for maximal transmission control of the virus, dental drug prescription considerations, and oral manifestations of COVID-19 infection.


  Materials and Methods Top


The information available from the literature and the clinical management of dental patients in the era of the COVID-19 pandemic was searched for in PubMed and Google Scholar. A literature search was performed to retrieve research articles with the content of COVID-19 and dentistry, and maxillofacial surgery. No attempt to exclude any information was made, to obtain all the possible articles. Therefore, no strict inclusion and exclusion criteria were applied. High quality and relevant articles were classified into 4 categories based on their content for answering the following questions:

  1. How should the dental patients be categorized for receiving dental treatments?
  2. What protective precautions should be considered for dental practice during the COVID-19 outbreak?
  3. What are the dental aspects of the drugs that are used for COVID-19 pandemic control?
  4. What are the oral manifestations of COVID-19 infection?



  Results Top


Categorization of the patients and case selection for dental treatments

Utilization of dental services experienced a 38% decline at the beginning of the COVID-19 outburst where the proportion of dental and oral infections increased from 51.0% to 71.9% during this era. In the meantime, the number of non-emergency patients was decreased by 70% as declared by Geu et al.[10]. Long and Corsar[11] also acknowledged a 57% decrease in daily attendances for dental abscesses while the proportion of admission-requiring abscesses increased notably from 35% to 80% which reflects the essential impress of urgent dental care during the pandemic.

Alharbi et al.[12] proposed a guideline through which dental health professionals would be able to categorize the patients to five divided groups after the meticulous screening of them in terms of COVID-19 infection: A (asymptomatic, unsuspected, unconfirmed), B (symptomatic/suspected, unconfirmed), C (stable, confirmed: mild infection with no hospitalization/oxygen therapy), D (unstable, confirmed: sever and critical cases), and E (recovered, confirmed: asymptomatic for at least 30 days after the last negative laboratory test). The authors have also classified the various dental treatments to five classes for easier decision making of the dentists by allocating each patient category to specific classes of dental treatment that can be implemented for the patients which is depicted in [Table 1]. According to this guideline COVID-19 infection status together with the urgency of a dental treatment leads to rationale decision making for the treatment of the patients under the premise of adequate protection measures. Although the authors suggested that full dental treatment can be implemented for recovered COVID-19 patients, Chen et al.[13] reported a case of SARS-CoV-2 reoccurrence in convalescence accentuating the active surveillance of the virus for infectivity assessment. Similarly, Loconsole et al.[14] reported the reactivation of COVID-19 in a patient after more than 30 days of the test negativity and emphasized on the fluctuant presence of the virus and possible occurrence of the false-negative results. A brief guide for interpretation of the COVID-19 viral and antibody tests is illustrated in [Figure 1].
Table 1: Categorization of dental patients and decision making for their treatment

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Figure 1: Interpretation of COVID-19 viral and antibody test results[15],[16]

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Protective precautions in the dental setting

Patient screening

Dental practitioners are advised to utilize telephonic pretriage for initial assessment of the patients by asking 3 pertinent questions including any recent travel history to any areas with a high incidence of COVID-19, any exposures to a person with suspected/known COVID-19 infection, and presence of any symptoms of the disease.[17] The positive response of the patients to any of the questions should be followed by deferring the dental appointment for up to 2 weeks and thus self-quarantining at home as suggested by Meng et al.[18] Therewith, body temperature and the presence of suspect symptoms should be assessed and registered at the dental office appointment.[19]

Waiting area

Parhizkar et al.[20] suggested a minimum of 6 feet distance between patients from one another/dental personnel in a sufficiently ventilated waiting room and emphasized on providing the patients with surgical face mask and hand sanitizer. GE et al.[21] suggested instructing the patients to cover their nose and mouth with a tissue or their elbows when sneezing or coughing followed by immediate disposing of the tissue and hand disinfection. However, they supposed that the 1-meter spatial distancing of the patients is adequate.

Hand hygiene

Hand washing plays a pivotal role in COVID-19 prevention.[18] As suggested by Peng et al.,[22] thorough hand washing is crucial when coming into contact with patients, surfaces, and equipment and touching nose, mouth, and eyes with contaminated hands has been restrictedly avoided. Soap and alcohol-based hand rubs (ABHR) are equally effective cleansers. However, handwashing with soap and water is capable of eliminating dirt, body fluids, blood, and any other visible hand contamination whereas ABHRs are appropriate sanitizers for hands that are not visibly soil.[21]

Pre-procedural mouth rinse

Despite the efficacy of chlorhexidine in the reduction of colony-forming units in dental aerosol, its effectiveness in eliminating COVID-19 is a matter of conjecture.[21],[23] Farzan and Firoozi[24] stated that Povidone-iodine (PVP-I) gargle/mouthwash is the only promising and approved substance for eliminating coronaviruses. In a recent study, Kirk-Bayley et al.[25] advocated the application of PVP-I nasal sprays together with povidone-iodine mouthwash for minimizing COVID-19 transmission through virus expectoration in the form of aerosols.

3.2.5 Personal protective equipment (PPE)

Concerning the transmission of the virus through airborne droplets in the dental setting, utilization of protective equipment such as gloves, facial masks, long-sleeved water-resistant gowns, shoe cover, eyewear and face shields is of utmost importance in the era of COVID-19.[8]

Although surgical masks protect mucous membranes of the nose and mouth for droplet spatter, they do not ensure full protection against inhalation of airborne transmissive agents as declared by the Centers for Disease Control and Prevention (CDC). Yet, the patients should be asked to re-don their face covering with a surgical mask after the dental treatment completion when they leave the treatment area as well as when they enter the dental office.[26] Working in close contact with patients necessitates utilizing particulate respirators such as filtering face piece (FFP) level 2/3 or N95.[8] Utilization of the protective safety glasses and face shields is mandatory when performing an aerosol-generating procedure as COVID-19 is capable of transmitting through human conjunctival epithelium.[27]

Contaminated air filtering

Two types of commonly used devices can be utilized for filtering the contaminated air within the dental office area: high-volume evacuator (HVE) and high-efficacy particulate arrestor (HEPA). HVE is a rather inexpensive device, capable of reducing the contamination of the operating site by 90% at 2.83 m3 per minute. However, this device should be held at a specific distance from the aerosol-generating instrument (6–15 mm) for proper operation. On the other hand, HEPA is an expensive air filtration device that can remove 99.97% of 0.3 μm particles.[21] Recent guidelines suggested by the CDC proposed the utilization of portable HEPA air filtration units during aerosol-generating procedures.[26] With 6 air changes per hour (ACH), a time gap of 46 minutes is required between patients for 99.9% removal of airborne contaminants by efficacy. As the 6–15 ACH has been frequently cited for patient-care areas, a range of 18–46 minutes of time gap is demanded between patient's appointments.[28]

Surface disinfection

Although coronaviruses are proven to persist on inanimate surfaces for up to 9 days, they are noticeably vulnerable to surface disinfectants containing 62–71% ethanol, 0.5% hydrogen peroxide, and 0.1% (0.1 g/L) sodium hypochlorite within 1 minute.[29]

The protective precautions for COVID-19 infection control in the dental setting are presented in [Table 2].
Table 2: Protective precautions in dental practice for control of COVID-19 transmission

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Considerations of drug prescription in dentistry practice

Analgesics

As the outburst of COVID-19 resulted in the limitation of dental practice to emergency treatments, patients with dental pain were compelled to rely on supportive therapy by analgesics and non-steroidal anti-inflammatory drugs (NSAIDs) administration for the alleviation of their pain. On the other hand, the mainstay treatment of mild-moderate COVID-19 patients is the analgesic supportive, antipyretic therapy which has to do with the administration of analgesics such as ibuprofen.[30] However, the exacerbation of the symptoms of COVID-19 patients followed by ibuprofen administration cast attention on the possible unfavorable effects of the drug.[31] Theoretically, the capability of ibuprofen in increasing the ACE2 bioavailability and interference with the immune system supported the enhancement of COVID-19 infection.[30],[32] Although no strong epidemiological evidence supported this pharmacological theory, dentists should keep a watchful eye on updates. Therefore, prescription of paracetamol or acetaminophen as the first-line drugs for dental pain relief is suggested as a cautious solution.[30],[32]

Azithromycin

Azithromycin is the empiric medication for odontogenic infection in penicillin-allergic patients and is a favorable antibiotic for the management of respiratory infections in children.[30] Despite the efficacy of a combined regimen of azithromycin and hydroxychloroquine in a few reports, no strong evidence has supported the alleged efficacy and safety of this regimen. Considering the shift of dental services to emergency treatments and therefore a possible increase in antibiotic prescription, dentists should be vigilant in prescribing azithromycin especially in countries with a high toll of COVID-19 patients to decrease the risk of antibiotics resistance and side effects. Amoxicillin or clindamycin are appropriate alternatives for azithromycin in the era of COVID-19 pandemic.[30],[32]

Chloroquine

Chloroquine attracted a lot of attention in the early outburst of COVID-19 with regard to its inhibitory effect on SARS-CoV-2 viral replication and its subsequent clinical efficacy. Chloroquines together with antiviral drugs such as remdesivir have demonstrated a remarkable efficacy and safety for the control of COVID-19 infection and therefore many countries have faced severe shortages of the drug. This is of paramount importance for the dentists to consider the influence of the drug shortage on chloroquine-dependent dental patients such as systematic lupus erythematosus (SLE) and Sjogren's syndrome patients with oral manifestations. Moreover, dentists should be acquainted with possible oral complications of chloroquine administration such as melanotic pigmentation and lichenoid reaction of the oral mucosa.[30]

Oral manifestations of COVID-19 infection

The presence of the COVID-19 genome in the saliva of the majority of the patients indicates potential infection of the salivary glands which makes saliva a dependable and comfortable alternative to naso/oropharyngeal for sampling.[33] Taste or/and olfactory disorders are common oral manifestations of COVID-19 as the virus penetrates taste buds of the tongue via ACE2 receptors. Therefore, dentists should be aware of any alterations in taste in forms of dysgeusia and burning mouth syndrome as they might be representative of respiratory diagnostic manifestation of COVID-19 infection.


  Discussion Top


The role of dental practitioners in preventing the transmission of COVID-19 is pivotal. Despite the suspension of routine dental care in many countries around the world, dental professionals perceive a moral duty to take part in the global fight against the pandemic. Additionally, dentists can also contribute to the initial diagnosis of the disease as it may represent with oral manifestations. Many aspects of the dental profession such as financial and psychological dimensions are at stake. Therefore, dentists need to be vigilant in the updated data, guidelines, and protocols that are related to their profession.


  Conclusions Top


In light of the protective precautions for the dental practice, dentists can perform safe dental treatment for the patients in the era of COVID-19 pandemic. Dentists should be able to categorize the patients based on their health status and treatment demands to make a moral and beneficial decision. Moreover, oral manifestations of COVID-19 turn dentists to frontiers in the diagnosis of the disease. As COVID-19 patients may represent asymptomatic or medically unexplained symptoms, a thorough screening of the patients in terms of specific or non-specific symptoms of infection and following protective precautions is of utmost importance in dental practice.

Author's contribution

Dr. F. R, Dr. M. Kh, and Dr. Gh. Sh contributed to the design and implementation of the research, and the writing of the manuscript. All authors have approved the final article.

Ethical approval

Not applicable

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.



 
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    Tables

  [Table 1], [Table 2]



 

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