Journal of Family Medicine and Primary Care

CASE REPORT
Year
: 2020  |  Volume : 9  |  Issue : 6  |  Page : 3157--3159

Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge


Nikhil Bush1, Vishal Sharma1, K Chandrahasan2, Amol N Patil2 
1 Department of Gastroenterology, Post Graduate Institute of Medical Education and Research, Chandigarh, India
2 Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India

Correspondence Address:
Dr, Amol N Patil
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh - 160012
India

Although ofloxacin-ornidazole fixed-dose combination (FDC) is a rampantly used antibiotic combination for mixed-infection diarrhea in India, the adverse drug reaction (ADR) associated with these FDCs remains underreported. Herein, the authors present a case report of a definitive ofloxacin-ornidazole FDC-induced pancreatitis. The nonalcoholic adult male patient showed a sharp piercing epigastric pain flowing to the back, gradually rising in severity, which started after taking ofloxacin-ornidazole FDC tablet over the counter. Serum lipase concentration measured in the emergency room was 635 units per liter (normal range- 13–60 units/L) and serum amylase was 377 units/L (normal range- 30–110 units/L). Ultrasonography and an axial computed tomography of the abdomen confirmed the diagnosis of acute pancreatitis. Ofloxacin-ornidazole FDC tablet was stopped immediately. Past treatment records confirmed accidental rechallenge. In conclusion, this is a first case report of ofloxacin-ornidazole FDC-induced pancreatitis.


How to cite this article:
Bush N, Sharma V, Chandrahasan K, Patil AN. Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge.J Family Med Prim Care 2020;9:3157-3159


How to cite this URL:
Bush N, Sharma V, Chandrahasan K, Patil AN. Ofloxacin-ornidazole fixed-dose combination medication-induced pancreatitis with positive rechallenge. J Family Med Prim Care [serial online] 2020 [cited 2021 Mar 2 ];9:3157-3159
Available from: https://www.jfmpc.com/article.asp?issn=2249-4863;year=2020;volume=9;issue=6;spage=3157;epage=3159;aulast=Bush;type=0